Focal Segmental Glomerulosclerosis
also Nephrotic Syndrome

• Must always be considered in any child who has Nephrotic Syndrome and does not undergo a remission within 4 weeks of beginning steroid therapy
• Clinical manifestations usually occur between 2-10 years of age
• Majority have hematuria
• May be primary or secondary to a variety of disease processes (e.g., sickle cell, reflux, etc.)
• Progresses to renal failure
• Treatment response is poor

CHLA Board Review 2005