Nephrotic syndrome
and Minimal Change, FSGS, Post-Infectious Glomerulonephritis, MPGN, IgA nephropathy (Bergers Disease))

Etiologies: minimal change disease (most common), FSGS, MPGN, and associated with systemic diseases (e.g., SLE, HSP, HUS). The first step in the evaluation is to obtain a thorough medical history and family history. In general, diseases that cause NS are not familial in origin, but the presence of disease in a family member may provide clues to the ultimate diagnosis.

Physical examination should focus on vital signs because severe NS may be indicated by:


Look at the pee:


Nephrotic Syndrome in Infants:

Congenital Nephrotic Syndrome:


Note:  The incidence of FSGS is on an exponential rise in children and must be suspected in any child who has NS and does not undergo a remission within 4 weeks of beginning steroid therapy.

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