Tumor Lysis Syndrome

• Hematopoetic tumors (especially Burkitt’s)
• Lab findings
  1. Hyperkalemia
  2. Hyperuricemia
  3. Hyperphosphatemia
  4. Hypocalcemia
  5. Lactic acidosis
• Treatment
  1. Treat electrolyte disturbances
  2. Alkalinize urine
     1. beware alkalinization of blood can cause a drop in free calcium and exacerbate hypocalcemia
  3. (HCO3 drip)
  4. Hydration
  5. Allopurinol
  6. Amphogel

CHLA Board Review 2005