Thin Basement Membrane Disease

1. Hereditary condition in which the lamina densa is decreased in width to less than 1000-2000 angstroms
2. Present with microscopic hematuria with dysmorphic RBCs without significant proteinuria
3. Confirmation with renal biopsy but may not needed if no significant proteinuria and close relatives have been biopsied
4. Good prognosis; monitor urinalysis periodically

CHLA Board Review 2005