Teratogenic drugs, fetal effects

Fetal Alcohol Syndrome



Marijuana: neonatal abstinence, fetal growth retardation

Tobacco: growth retardation; increased incidence of placenta previa and abruptio placenta


Carbamazepine: similar to fetal hydantoin syndrome

Valproic acid: craniofacial abnormalities, spina bifida, congenital heart disease

ACE inhibitors (captopril and enalapril, especially during 2nd and 3rd trimesters): growth retardation, rare skull ossification defects, neonatal acute renal failure


Magnesium Sulfate: respiratory and neuromuscular depression

Diethylstilbesterol: clear cell adenocarcinoma of the vagina in the offspring of women treated with this agent
References: Behrman RE, Kliegman RM, Jenson HB. Nelson Textbook of Pediatrics 16th ed. WB Saunders, Philadeplphia 2000.