Recommended Treatment Regimens for Tuberculosis
Latent TB infection (positive PPD, no disease)
- 9 mo of INH, qd (or DOT twice a week if daily therapy not possible) OR
- 6 mo of rifampin qd (if INH resistant)
- Contact specialist if INH-rifampin resistant
Pulmonary and extrapulmonary (except meningitis)
- Triple therapy x 2 mos, then double therapy x 4 mos.
- 2 mo of INH, rifampin, and pyrazinamide daily (additional drug if
resistance is a concern), followed by 4 mo of INH and rifampin
- If hilar adenopathyonly, a 6 mo course of INH and rifampin is sufficient
Meningitis
- Quadruple therapy x 2 mos, then double therapy x 7-10 mos.
- 2 mo of INH, rifampin, pyrazinamide, and an aminoglycoside or ethionamide,
once a day, followed by 7-10 mo of INH and rifampin once a day or twice a week
(9-12 mo total)
- Add corticosteroids if meningitis; and can consider for pleural and
pericardial effusions, sever miliarydisease, and/or endobronchial disease