T-cell defects overview

• "Opportunistic" infections: Viral, Fungal, Bacterial
  • Mycobacteria, CMV, EBV, Varicella, PCP, enterovirus, candida
• May also present with bacterial infections b/c of role of T-helper cells with humoral immunity
• GI symptoms (diarrhea)
• FTT
• Oral candidiasis (intractable or >1 year old)
• HSM/LAD
• Severe seborrhea-like dermatitis
• Poor survival
• Specific disorder phenotypes