Sydenham Chorea

• Frequent, brief, unpredictable, purposeless movements
• Basal ganglia disorder

Clinical triad of:

• Chorea
• Hypotonia/weakness
• Emotional lability / OCD / ADHD

Treatment:

• Anti-epileptics: (valproate, carbamazepine), benzodiazepines
• Immunomodulation (IVIG, plasma exchange, steroids)
• Cardiac (penicillin prophylaxis –5 yrs or until 21 yrs of age, whichever is longest if without carditis; longer if carditis or residual heart disease)

CHLA Board Review 2005