SCID
See BMT

Problem: profoundly defective or absent T-cell and B-cell function; small thymus, lymphocyte-depleted spleen

Epidemiology: 1/50,000-100,000

Presentation:

Two Major Types

Treatment:

Interesting Note: In normal fetuses, after the 13th week of gestation the immune system works well enough to reject foreign cells (including maternal). In SCID babies who are not immunocompetent, the fetus cannot reject maternal blood, and will have maternal cells in their body at birth. In boys, some cells may be XX (maternally derived), in girls, looking at DNA fingerprinting (short tandem repeats), some of momís cells may be present.

See BMT