Rapidly Progressive (Crescenteric) Glomerulonephritis

1. crescents found in the majority of glomeruli
2. (note that crescents may be found in many other forms of glomerulonephritis, but often can make the diagnosis based on other findings and labs; if other forms are excluded, then probably have idiopathic RPGN)
3. labs to exclude other etiologies; diagnosis confirmed by kidney biopsy
4. most patients develop acute renal failure; progression to end-stage renal failure follows within weeks to months.
5. prognosis can vary based on etiology; e.g., children having RPGN associated with post-strept glomerulonephritis may recover spontaneously

CHLA Board Review 2005