Oligohydromnios, Pulmonary hypoplasia, Intrauterine vesicoamniotic
shunting
Pulmonary Hypoplasia
Amniotic fluid volume is a good indicator of fetal renal function and of the
potential success of vesicoamniotic shunting.
Failure of urine to fill the amniotic
space leads to progressive
oligohydramnios, which results in
poor pulmonary growth. The primary cause of death in
prenatally diagnosed obstructive
uropathy is pulmonary hypoplasia.
The degree of renal dysplasia and pulmonary hypoplasia depends on the
gestational age at onset and the duration of obstruction.
Intrauterine relief of obstruction
and restoration of amniotic fluid volume leads to normal lung growth and
development, which is the basis for
vesicoamniotic
shunting as a means of preventing pulmonary
hypoplasia.
The shape of the urinary bladder, rather
than its volume, determines the outcome following
vesicoamniotic
shunting. Complete obstruction of the urethra, as in urethral atresia,
leads to a round, thick-walled bladder. In contrast, partial obstruction of the
urethra, as in posterior urethral valve, results in a tubular shape with
symmetric wall thickening. Functional obstruction of the urethra, as in prune
belly syndrome, leads to a segmented bladder appearance, with thinning of
the dome and thickening of the bladder neck. Urethral atresia carries a
poor prognosis.
In female fetuses, lower urinary tract obstruction often is associated with
developmental anomalies of the cloaca and other syndromic abnormalities. In
contrast, male fetuses usually have an isolated urethral obstruction.
Female gender, therefore, carries a poor
prognosis for intrauterine intervention.
Analysis of fetal urine for electrolytes has been proposed as a test for
determining the outcome of vesicoamniotic shunting. Hypertonicity of urine from
salt wasting is believed to indicate poor renal function and, hence, a poor
outcome. However, this interpretation remains unconfirmed. Moreover, the
measurement of urine electrolytes from a single bladder drainage may not
be predictive of fetal renal function.
Ultrasonographic measurement of the renal pelvis diameter has been proposed as
another test for determining the outcome of vesicoamniotic shunting. However,
the usefulness of this test is controversial.Continued surveillance of renal
pelvis diameter at various gestations
and correlation with postnatal diagnosis and outcome are needed.
References:
Jona JZ. Advances in fetal surgery. Pediatr Clin North Am. 1998;45:599-604
Walsh DS, Johnson MP. Fetal interventions for obstructive uropathy.
Semin Perinatol. 1999;23:484-495