Prothrombin 20210A Mutation

• Single point mutation leading to elevated levels of prothrombin and increased venous thrombosis
• 1-2% of Caucasians are heterozygotes
• 2nd most common inherited hypercoag state in the Dutch population
• 3-5x increase risk for DVT
• Up to 40% also have Factor V Leiden mutation
• Diagnosed by PCR of the gene

return to Hypercoaguable states

CHLA Board review 2005