Moebius Syndrome (Congenital Facial Diplegia)

• mask-like facies; don't know how to smile, +/- mental retardation
• 6th (abducens) and 7th nerve  (facial) palsies; can be central or peripheral nerves, unilateral or bilateral
• micrognathia; "convergent squint"
• also: epicanthic folds, ear abnormalities, defective branchial musculature
• in some cases, limb defects: syndactyly, polydactyly, brachydactyly, oligodactyly, absent trapezoid or pectoral muscles
• Considerable overlap with Poland syndrome and hypoglossia-hypodactyly syndrome

CHLA board review course 2005
Baraitser and Winter, 1996. Color Atlas of Congenital Malformation Syndromes