Membranoproliferative Glomerulonephritis
also
Nephrotic Syndrome
- most common cause of chronic
glomerulonephritis in
older children and adults
- most common in the 2nd decade of
life
- most patients present with
nephrotic syndrome, and others with gross
hematuria or
asymptomatic microscopic
hematuria and proteinuria
- renal function may be depressed;
hypertension is common; C3
level may be low
- may be indistinguishable from
post-strept
glomerulonephritis,
since both may have gross hematuria, low C3, and elevated ASO titers (which
may be coincidental), but PSGN improves dramatically within 2 months of onset,
whereas MPGN persists
- poor prognosis; most progress to
end-stage renal failure
CHLA Board Review 2005