Hepatocellular carcinoma

• Median age is…12 yrs
• Presents as a multicentric invasive tumor
• 50% have elevated AFP levels
• Associated with hepatitis B infection
• Long term survival 30% with resection and chemotherapy

Hepatoblastoma vs Hepatocarcinoma

• Age of presentation: HB 1 yr, HC 12 yrs
• Liver distribution: HB unifocal, HC multifocal
• Associations: HB Beckwith-Wiedemann, HC Hep B
• Survival: HB 90%, HC 30%

CHLA Board Review