Hemoglobin

Hemoglobinopathies

Hgb C

Hb SC

Hgb S β-thal

Hemoglobin E: beta-chain variant (alpha2 / beta2, 26Glu->Lys); prevalent in populations from Southeast Asia, particularly Thailand and Cambodia

  1. trait no anemia, but microcytic
  2. homozygous mild anemia, microcytic, no organomegaly
  3. E-beta-thalassemia similar to beta-thalassemia major; characterized by severe anemia, organomegaly from extramedullary hematopoiesis, and hemolysis; requires RBC transfusion