Heme/Immunology primer

Host Defenses

Innate immunity is Non-specific

Adaptive immunity is antigen specific

Disorders of Phagocyte dysfunction (innate immunity)

  1. Disorders of chemotaxis: Hyper IgE Syndrome
  2. Adhesion Abnormalities: Leukocyte Adhesion Deficiency
  3. Degranulation Abnormalities: Chediak-Higashi syndrome
  4. Defects of Microbial Activity : Chronic granulomatous disease

Complement defects (innate immunity)

  1. Initial defects: Association with autoimmune disorders
  2. Terminal defects: Increased risk of infection
  3. C1 Esterase Inhibitor