Familial Mediterranean Fever (FMF)
also see Fever, Periodic
A periodic fever syndrome. Attacks occur at irregular intervals; resolve in 12-72 hours. Recurrent self-limiting attacks of:
Who? Common among Sephardic Jews
Why? Due to failure to degrade C5a. Autosomal recessive trait
Labs? WBC, ESR, CRP, fibrinogen elevated during attack
Tx? Regular treatment with colchicine to prevent attacks and secondary amyloidosis
CHLA Board Review 2005