Cefuroxime (Ceftin) -- Second-generation cephalosporin that maintains gram-positive activity of first-generation cephalosporins and adds activity against P mirabilis, H influenzae, E coli, K pneumonia, and M catarrhalis. Condition of patient, severity of infection, and susceptibility of the microorganism should determine proper dose and route of administration. (Disulfiramlike reactions may occur when alcohol is consumed within 72 h after taking cefuroxime; may increase hypoprothrombinemic effects of anticoagulants; may increase nephrotoxicity in patient receiving potent diuretics such as loop diuretics; coadministration with aminoglycosides increases nephrotoxic potential)

Cefaclor (Ceclor) -- Second-generation cephalosporin indicated for infections caused by susceptible gram-positive cocci and gram-negative rods.

Second Generation cephalosporines with anaerobic activity: cefotetan and cefoxitin

Ceftriaxone (Rocephin) -- Third-generation cephalosporin with broad gram-negative spectrum, lower efficacy against gram-positive organisms, and higher efficacy against resistant organisms.
By binding to one or more of the penicillin-binding proteins, arrests bacterial cell wall synthesis and inhibits bacterial growth.

Cefepime: 4th generation cephalosporin