CATCH 22 = mnemonic for DiGeorge syndrome

• Cardiac - aortic arch anomalies, conotruncal (TOF, truncus arterious, interrupted aorta), tricuspid atresia,
• Abnormal facies - hypertelorism, ear anomalies, short down slanting palpebral fissures (antimongoloid), short philtrum
• Thymic hypoplasia - cellular immune deficiency: abnormal number and function of T-cells)
• Cellular immune deficiency; Cleft palate
• Hypoparathyroid with hypocalcemia - tetany
• 22 chrom defect deletion 22q11; dx by FISH